The Azzurri are currently enjoying a 27-match unbeaten streak, though they remain just behind the absolute favourites, including France, England and Belgium.
They are joined by Wales and Switzerland in Group A, with Mancini eager to replicate the group stage performance of Euro 2016, when they topped a group including Belgium, including a fine 2-0 win over the Red Devils to kick off their campaign, which ended in the quarter-finals with a penalty shoot-out defeat to Germany.
Turkey, meanwhile, appear primed to cause an upset or two this summer and are led by Lille’s Ligue 1-winning striker Burak Yilmaz, while Şenol Güneş’ side also possess a sturdy defence.
Here’s everything you need to know about the game at the Stadio Olimpico in Rome
When is the match?
Turkey vs Italy is scheduled to start at 8pm BST on Friday, 11 June, signalling the start of Euro 2020.
The game will take place at Stadio Olimpico in Rome, Italy, home of Roma and Lazio, while there will be 25-45 per cent of the stadium’s capacity to provide the Azzurri with home support.
Where can I watch on TV and is there a live stream?
You can watch the game on BBC One for free, while there will also be a live stream for UK viewers on the iPlayer. Coverage starts at 7pm BST.
What is the team news and who is in the squad?
Mancini will opt for a 4-3-3 here, Donnarumma will sit between the sticks behind Bonucci and Chiellini, while Florenzi has a minor knock, which could mean Di Lorenzo steps in and Spinazzola should be preferred to Emerson on the left.
Jorginho, fresh from his part in Chelsea’s Champions League triumph, will pair up alongside Barella, while Locatelli may be the third member of that midfield ahead of Pellegrini, given Verratti is not in peak condition. Insigne and Immobile are sure to start with Chiesa likely to edge out Berardi for that final spot.
Goalkeepers: Gianluigi Donnarumma, Alex Meret, Salvatore Sirigu
Defenders: Francesco Acerbi, Alessandro Bastoni, Leonardo Bonucci, Giorgio Chiellini, Giovanni Di Lorenzo, Emerson, Alessandro Florenzi, Leonardo Spinazzola, Rafael Toloi
Midfielders: Nicolo Barella, Bryan Cristante, Jorginho, Manuel Locatelli, Lorenzo Pellegrini, Stefano Sensi, Marco Verratti
Forwards: Andrea Belotti, Domenico Berardi, Federico Bernardeschi, Federico Chiesa, Ciro Immobile, Lorenzo Insigne, Giacomo Raspadori
Turkey will have Demiral and Soyuncu at the back, with talisman Yilmaz leading the line, with Calhanoglu and his set-piece delivery sure to be key at this tournament.
Goalkeepers: Altay Bayındır, Mert Günok, Uğurcan Çakır
Defenders: Zeki Çelik, Çağlar Söyüncü , Kaan Ayhan, Merih Demiral, Mert Müldür, Ozan Kabak, Rıdvan Yılmaz, Umut Meraş
Midfielders: Yusuf Yazıcı, Dorukhan Toköz, İrfan Can Kahveci, Okay Yokuşlu, Orkun Kökçü, Ozan Tufan, Taylan Antalyalı, Hakan Çalhanoğlu
Forwards: Burak Yılmaz, Cengiz Ünder, Enes Ünal, Abdülkadir Ömür, Kerem Aktürkoğlu, Halil İbrahim Dervişoğlu, Kenan Karaman
Italy (4-3-3): Donnarumma; Di Lorenzo, Bonucci, Chiellini, Spinazzola; Barella, Jorginho, Locatelli; Chiesa, Immobile, Insigne.
Turkey (4-1-4-1): Çakir; Celik, Söyüncü, Demiral, Meras; Yokuslu; Karaman, Yazici, Tufan, Calhanoglu; Yilmaz.
We’ll opt for a home win here, but this could be a rollercoaster given Turkey’s ability to mix it with the heavyweights of European football. But the Azzurri ease to a 2-1 victory in Rome.